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Conventional MRI sequences have limited specificity for myelination.
We evaluate the imaging modalities which are potentially more specific to myelin content in vivo, such as magnetisation transfer ratio (MTR), restricted proton fraction f (from quantitative magnetisation transfer measurements), myelin water fraction and diffusion tensor imaging (DTI) metrics, in addition to positron emission tomography (PET) imaging.
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Trials of potential neuroreparative agents are becoming more important in the spectrum of multiple sclerosis research.