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Where then are the genes responsible for the cognitive deficits?6 million years ago a 3.5 Mb block on the X chromosome long arm was duplicated onto the Y chromosome short arm.They are also abilities which most clearly differentiate the sexes.Although with considerable overlap females have an advantage in the acquisition of words and males in tasks involving spatial ability.This can be understood as ' dosage compensation ' between males and females that ensures that genes on the X are expressed to approximately the same extent in either sex.The rule is that one X remains active, and extra X's are inactivated.As far as is known aneuploidies of the sex chromosome occur in all human populations, probably with the same frequency.If true this suggests that the phenomenon reflects a baseline ' mutation rate ' associated with the mechanism of meiosis.

Often these individuals are unaware of their condition; this may come to light in routine cytogenetic surveys in infancy, or through infertility clinics.

There is also a strong case that speciation events are related to the sex chromosomes, particularly the X.

Relatively little is known about the frequency or even the occurrence of sex chromosome aneuploidies in other mammalian species.

Since the aneuploidy deficits are the same in XXY who are male, and XXX individuals who are female, these must be genetic and not hormonal in origin.

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The acquisition of words and the ability to represent the outside world in a spatial format are aspects of cognition that arguably are human specific.

In the Descent of Man Darwin expressed the opinion that the mechanism of sexual selection which he had differentiated from the process of natural selection was somehow involved in the origins of Homo sapiens, but he did not specify how.

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